Medicinal chemists are often engaged in selecting a disease to target for drug development, a biological target at which drug action can produce a positive therapeutic outcome in individuals with the disease, identify and prioritize candidate compounds to be tested against the biological target, and synthesize the most promising candidates for those experimental assays. Throughout the course, you will engage in these activities, and present your work in the form of a research proposal (to be developed in stages through the semester, with feedback after each stage). The research proposal should illustrate the importance of finding new therapeutic leads for your chosen disease. It should provide background information on the disease that demonstrates your biological target is a reasonable direction for drug discovery and development. It should include your modeling data to convince readers that your proposed structure has a reasonable chance of acting at the intended biomolecular target. It should outline a synthetic plan to prepare the proposed new drug candidate, and discuss problems that might occur during execution of the project. A good proposal is likely to require around 8-10 pages to ensure all the required elements are done well. The process of developing this research proposal has been divided into parts 1-3, with both peer-review and instructor feedback on each major new component prior to completion of the final project (called Part 4).
Project part 1 should look like the introduction to a manuscript or grant proposal, and should include the following elements:
Project part 2 should include the following elements:
Project part 3 should include the following elements:
Your final project should include all three of the previously reviewed parts, with appropriate revisions to address additional feedback.